Oxycodone carries many Boxed Warnings for possibility of dependancy, overdose, and Demise; significant or lethal respiratory melancholy; fatalities from accidental ingestion by young children; deadly Unwanted effects when used with other respiratory depressants or CYP3A4 inhibitors; the chance of Neonatal Opioid Withdrawal syndrome in infants born dependent on oxycodone; along with the Opioid Analgesic REMS application.
Usually do not abruptly discontinue OXYCONTIN in patients who could possibly be bodily depending on opioids. Immediate discontinuation of opioid analgesics in sufferers that are bodily depending on opioids has resulted in severe withdrawal symptoms, uncontrolled soreness, and suicide.
Display screen patients for hazard of material use Issues, which include opioid abuse and misuse, and alert them of the chance for overdose and Dying connected with the use of extra CNS depressants together with Liquor and illicit medicines [see DRUG INTERACTIONS].
Instruct clients to swallow OXYCONTIN tablets entire; crushing, chewing, or dissolving OXYCONTIN tablets can cause rapid launch and absorption of a probably deadly dose of oxycodone [see WARNINGS AND Safeguards].
Productive towards significant discomfort which include suffering due to cancer. OxyContin is prolonged-Long lasting and only really should be taken two times every day.
Don't maintain leftover opioid medication. Only one dose may cause death in a person working with this medication accidentally or improperly. Check with your pharmacist wherever to Track down a drug consider-back again disposal system. If there isn't any just take-back again system, flush the unused medicine down the toilet.
Cytochrome P450 3A4 Interaction The concomitant use of oxycodone with all cytochrome P450 3A4 inhibitors may possibly end in a rise in oxycodone plasma concentrations, which could improve or extend adverse reactions and could lead to most likely fatal respiratory melancholy.
The concomitant utilization of anticholinergic get more info medicine may boost chance of urinary retention here and/or significant constipation, which can produce paralytic ileus.
Any person can purchase naloxone from the pharmacy or regional overall health Section. Be sure any person caring to suit your needs understands in which you preserve naloxone and the way to utilize it.
Speak to your healthcare provider about naloxone, a medication with the unexpected emergency cure of an opioid overdose.
When OXYCONTIN therapy is initiated, discontinue all other opioid analgesics besides These used on an as needed foundation for breakthrough soreness when acceptable.
Accidental ingestion of even one particular dose, particularly in youngsters, may result in a deadly overdose of oxycodone.
Before having oxycodone, notify your medical doctor or pharmacist If you're click here allergic to it; or to other opioid discomfort relievers (such as oxymorphone); or When you have another allergic reactions.
The concomitant usage of OXYCONTIN and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in greater or extended opioid results.